RFI Ingredients, Blauvelt, NY, reports its OxyPhyte® Natural Antioxidants now have proven cellular uptake and activity using the CAP-e (Cell-based Antioxidant Protection in Erythrocytes) assay. The CAP-e assay recently received the prestigious , an annual award recognizing research-based ingredients or technology innovation.
The CAP-e assay evaluates the antioxidant potential of a substance only if the substance is able to cross the lipid bilayer cell membrane. This ex vivo test uses human erythrocytes (red blood cells), which are inert and therefore do not produce reactive oxygen species. The red blood cells are exposed to the antioxidant substances and oxidation is triggered by the addition of a free radical generator. The oxidative damage within the cell is then measured as the relative fluorescence resulting from the reaction of the reactive oxygen species with fluorescent dye.
The CAP-e data answers the question of whether the antioxidants are able to enter living cells and protect the cell from oxidation. Results with the OxyPhyte® ingredients show that each ingredient has cellular bioavailability and prevents oxidation within the cell. In fact, the results of the study show that all the OxyPhyte® ingredients tested have better cellular uptake than quercetin, a pure antioxidant compound.
OxyPhyte® Antioxidants are the only antioxidants on the market with confirmed cellular uptake and activity using this latest technology in antioxidant testing. This advanced testing provides additional evidence supporting our OxyPhyte® products' antioxidant potency.
"Ten years ago, before ORAC became synonymous with antioxidant activity, RFI was the first company to standardize and guarantee ORAC levels in our OxyPhyte® Antioxidant line of products," explains Jeff Wuagneux, President and CEO of RFI. "As the science and technology behind antioxidant testing grows, RFI's mission is to go beyond ORAC and put together the full antioxidant puzzle for our OxyPhyte® antioxidant products. With the new CAP-e results, we now have another piece of the puzzle that shows proven cellular uptake, something that is not predicted by ORAC values."
OxyPhyte® Natural Antioxidants are available for use in dietary supplements, functional foods and beverages.
RFI Ingredients is a vertically-integrated manufacturer of innovative natural ingredients for the food, functional food and dietary supplement industries. The company, which was formed in 1989, specializes in the supply of quality ingredients (including certified-organic) and proprietary formulations.
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